Trazodone Hydrochloride EP Impurity I CAS 32229-98-4(Free Base)
| CAS No. | 32229-98-4(Free Base) |
| Molecular Formula | C13H19ClN2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Trazodone Hydrochloride EP Impurity I meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Trazodone Hydrochloride EP Impurity I (CAS 32229-98-4(Free Base), C13H19ClN2OHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Trazodone Hydrochloride EP Impurity I (C13H19ClN2OHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H19ClN2O HCl |
| Molecular Weight | 291.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Trazodone Standards
- Trazodone Impurity N13 (CAS 101364-27-6)
- Trazodone D6 (CAS 1181578-48-2)
- Trazodone-d6 Hydrochloride (CAS 1181578-71-1)
- Trazodone Hydrochloride EP Impurity C (CAS 1263278-77-8)
- Trazodone Impurity 4 (CAS 1263278-79-0)
- Trazodone EP Impurity D HCl (CAS 1263278-80-3)
- Trazodone Hydrochloride EP Impurity J (CAS 1263358-12-8)
- Trazodone EP Impurity D (CAS 1263358-13-9)
Recommended Standards
- Lifitegrast Impurity 18 (CAS CATO-C4X-240918)
- Tetrabenazine Impurity 27-D6 (CAS CATO-C4X-274827)
- Ketotifen Impurity 26 (CAS CATO-C4X-204626)
- Tert-butyl (S)-(4-(7-oxo-2-oxa-5,8-diazaspiro[3.5]Nonan-6-yl)butyl)carbamate (CAS 1839060-87-5)
- (2Z)-N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)-3-[(4-methoxyphenyl)amino]-N-methyl-2-phenylprop-2-enamide (CAS 337919-79-6)
- Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (CAS 179064-00-7)
- 2-(Isopropylamino)-2-oxoethyl 5-bromonicotinate (CAS 730251-61-3)
- 5-Amino-6-chloro-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 1128-14-9)
- N-(Benzo[d][1,3]dioxol-5-ylmethyl)-2-chloroacetamide (CAS 40023-03-8)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
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